Neuropixels Data Analysis

Overview

Toolkit for analyzing Neuropixels high-density neural recordings using current best practices from SpikeInterface, the Allen Institute, and the International Brain Laboratory (IBL). It covers the full workflow from raw data to publication-ready curated units.

All examples use the real SpikeInterface API (spikeinterface.full as si) plus the companion curation module (spikeinterface.curation as sc). The skill ships runnable scripts in scripts/ and a copy-and-edit template in assets/ that implement this workflow directly on top of SpikeInterface — there is no separate package to install beyond the dependencies listed under Installation.

When to Use This Skill

This skill should be used when:

• Working with Neuropixels recordings (.ap.bin, .lf.bin, .meta files)
• Loading data from SpikeGLX, Open Ephys, or NWB formats
• Preprocessing neural recordings (filtering, common reference, bad-channel detection)
• Detecting and correcting motion/drift
• Running spike sorting (Kilosort4, SpykingCircus2, Mountainsort5, Tridesclous2)
• Computing quality metrics (SNR, ISI violation…