Scientific Hypothesis Generation

Turn an observation into a transparent set of candidate explanations and tests. A hypothesis is a proposal to be challenged, not a finding, fact, diagnosis, or recommendation.

Non-negotiable boundaries

Before using unpublished, sensitive, controlled, personal, proprietary, export-controlled, or security-relevant material:

1. Confirm authorization and the applicable institutional, funder, publisher, data-use, privacy, and AI policies.
2. Keep the material local unless an authorized human explicitly approves a named external destination and data scope.
3. Minimize inputs. Do not place sensitive or unpublished data in web searches or external AI systems without authorization.
4. Stop at the appropriate human, animal, biosafety, dual-use, data-governance, or regulatory gate.

Never:

• present a hypothesis, mechanism, causal effect, citation, or apparent pattern as established evidence;
• claim novelty because a quick search found nothing;
• infer causation from association, temporal order alone, predictive accuracy, or model output;
• supply patient-specific diagnosis, treatment, dose, prognosis, or other clinical advice;
• provide harmful exp…